Some guy did some detective work and aggregated the ‘last played’ data of gamercards across the Internet to come up with a totally unofficial but probably not-too-far-off accounting of sales numbers for Xbox Live Arcade titles.
According to the list, more people have Uno than any other Arcade title and Texas Hold ‘Em is the biggest moneymaker.
Of course Uno comes free with the Vision camera and Hold ‘Em was free for the first two days of its release, so those two probably shouldn’t count.